RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
Miat
RNA ID
RNA Type
lncrna
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
PCR; dual-luciferase reporter assay etc.
Target
MIR-24;FURIN
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
MIAT Is a Pro-fibrotic Long Noncoding RNA Governing Cardiac Fibrosis in Post-infarct Myocardium
Year
2016
Function
Knockdown of endogenous miat by its sirna reduced cardiac fibrosis and improved cardiac function and restored the deregulated expression of the fibrosis-related regulators.